From the hardware perspective to address issues with NUMA:
1. Intel has implemented dual QPI (Quick Path Interconnected) link, a dual high-speed interconnect between their CPUs for remote memory access; this implemented on their new E5-Sandy Bridge processor. Can wait to see this happen on their E7 series processor!

2. Follow closely best-practice guideline when you install your DIMM (Dual Inline Memory Module) into the server. Few rules of thumb to remember, especially when you are using Intel platform:
– Remember, you want to avoid ‘remote-memory-access’ to happen. So, you will need to ensure that you distribute/spread your DIMM, across all memory channels in the system!
– After distribute all the DIMMs across all channels, all CPUs, when you sum up your DIMM, you will need to ensure that each channel has the same DIMM capacity.
E.g: If you are using E5 2600 series processor, 4 memory channels,
CPU1:
Channel 1: 1x1GB = 1GB
Channel 2: 2x512MB = 1GB
Channel 3: 2x512MB = 1GB
Channel 4: 1x1GB = 1GB

CPU2:
Channel 1: 1x1GB = 1GB
Channel 2: 2x512MB = 1GB
Channel 3: 1x1GB = 1GB
Channel 4: 1x1GB = 1GB

As we can see, each of the channel can have a different number of DIMM (some use 1 piece of 1GB, some can have 2 pieces of 512MB, but each of the channel they all have the same total capacity of 1GB!
– Always install DIMM from the last slot of each of your memory channel.

— voodoo doctor–